"But it takes only 2 seconds to edit the email address."Sorry, my thinking unit is fully utilized by the task of composing a good reply. If you want me to do any more thinking, I simply won't reply. If you want that, please write "Please don't send replies" in the main text of your posting (not in the sig). Or better, don't post in the first place.
To edit the email address, first I would have to notice that it is faked. Checking for that takes two seconds for every posting, 90% of which have working email addresses. So the checking alone would cost me 20 seconds per faked address.
If I notice the faked address, I usually don't reply or followup. Usually I add people with faked email addresses to my kill file, in order to avoid replying to address fakers in the future. I have already killfiled everyone who has spam or invalid in their From: address (unfortunately, my newsreader does not allow killing dependent on the Reply-To: field). So, if you insist on using a faked email address, please append .invalid.
The real trouble is when I don't notice the faked address. Then I take some time to compose the reply, only to get it back as undeliverable. And then I really get angry. If I still wanted to deliver the reply (which I don't), it would take me one minute or more: Call up elm, read the mail, find out the real address (which may not be apparent in the mail), forward the mail there, delete it, and leave elm.
Worse, some people use faked addresses of machines that exist. E.g., one I tried to respond to used nospam@please.com; please.com exists. Others use somewhere.com. In this case the admins of both faked addresses (the address used by the junk emailer, and the address used by the poster) get the junk email.
One idea I have to improve the effectivity of junk mail filtering is to use different, but working addresses in the From: and the Reply-To: fields, and to filter out everything I receive on both addresses (optionally add the Sender: field or the signature).
There are lots of other hints in various places. A good starting point for more advice is Get that Spammer.
If you are admin of an MX host, disable arbitrary relaying of email through your host if you have not already done so; if you don't, and junk emailers find your machine, you'll have a lot of trouble. If you want to do more, you can turn your host into a Teergrube (tar pit) for junk emailers. Or, more extremely, you can blackhole junk emailers and their relays.